Southeast Asian Journal of Case Report and Review
Official Publication of Association of Biomedical Scientists
Official Publication of Association of Biomedical Scientists
Online ISSN: 2319-1090
Southeast Asian Journal of Case Report and Review is a Peer-reviewed, International medical journal Published by the Association of Health Professionals. It will publish 04 issues per year will publish a research paper prepared by Health Professional. Journal will Give Preference to Case Report and Review Article Aim and Scope The aim and commitment of the journal is to publish a research-oriented manuscript on significant issues in all the subjects and areas of Medical Science including Genome mutation and Pathogenicity in microbes. Journal more...Original Article
Author Details :
Volume : 9, Issue : 4, Year : 2022
Article Page : 86-91
https://doi.org/10.18231/j.sajcrr.2022.018
Abstract
The aim of the present study is the Evaluation, preparation, and description of chitosan nanoparticles and bioavilibility enhancement of rivaroxaban. Preparation of Rivaroxaban nanoparticles (RB-NPs) were prepared by the ionic gelation method. Different parameters were studied for evaluation, Preparation & description of nanoparticles. The results of the present study showed that the formulation F7 showed the significant results for all the selected parameter as compared to the other formulations. The formulation F1, F5, and F6 showed the highest production yield (52.5, 52.35, and 52.35% respectively) and F7 showed the significant production yield (51.85%), zeta-potential (23.63 mV), entrapment efficiency (99.87), particle size (316.12±2.14 nm) and poly disparity index (0.32). Nanoparticles are solid colloidal drug carriers ranging from 10—1000 nm in diameter and are composed of synthetic, natural or semi-synthetic polymers encapsulating the drug molecule.
Keywords: Chitosan, Nanoparticles, Polymers, Rivaroxaban
How to cite : Jalaluddin M, Dar M S, Tahir A, Sahu D, Evaluation, preparation, and description of chitosan nanoparticles, as well as improving rivaroxaban bioavailability. South Asian J Case Rep Rev 2022;9(4):86-91
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